(Phys.org)—A key chemical component to antibiotics, such as penicillin is the beta-lactam, a four-membered amide ring that is fused to another heterocycle. Researchers in drug design would like to explore compounds using a similar structure. One avenue may be found in the four-member azetidine ring. Similar to the beta-lactam ring, it is a four-membered amine heterocycle. However, less progress has been made for benzazetidines, an azetidine fused to a benzene ring, due to the significant ring strain in these four-membered scaffolds.
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