A team of scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), led by Prof. Francisco Sánchez-Madrid, has characterized a cell signal that impedes intercellular communication and could play a central role in biomedical strategies such as gene therapy, vaccine design, and immunotherapy. The study, published today in Nature Communications, characterizes a signal that impedes the secretion of nanovesicles called exosomes. Cells secrete exosomes as a means of intercellular communication; however, certain viruses can use exosomes as "Trojan horses" to facilitate their propagation and entry into neighboring cells.
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